Tiny Magnets Find Brain Cancer Cells Be aware! A persistent head-ache today may be a serious brain tumour tomorrow Nupur Fangaria Loka Biosciences Pvt. Ltd. A 40-year-old man has been suffering from a persistent headache with a feeling of nausea for a month. He finally visits the doctor who suggests he undergo an MRI scan. …
Organoids: More than tissue culture and not less than animal models! Karthic A SIIPL, Pune Inventing or discovering a new medicinal drug takes an average of 10 years from mind to market. It is due to the extensive regulation involved in assessing the safety and efficacy of any new active pharmaceutical ingredient in its administrable …
Organoids: More than tissue culture and not less than animal models! Read More »
Sindhu M Indian Institute of Science, Bengaluru A group of 15-20 bioengineers huddled around a machine while Vikas Garg explained how it could someday be the future of food technology. The machine is a 3D printer, which can shape silicone, a notoriously difficult material. Vikas is the co-founder of Prayasta, a startup that currently 3D …
Vast Potentials of Microphysiological Systems Sudeepa Nandi Tata Institute of Fundamental Research, Mumbai With a growing need in the biomedical field, it is imminent to find the best of model systems to address basic and translational questions. For decades, 2D cultures have been used immensely, for disease modelling studies to test drugs for diseases. However, …
An Original 3D Culture Model: Human Pancreatic Cancerous Organoids Generated in Liquid Pearls Christian D. Muller Dr. ès Sciences, Ph.D. CSO & Founder, PearlBioSystem In recent years, interest in medicinal Cannabis sativa L. has been rising, as legislation is moving in the right direction. In our laboratory we compared different cannabinoid extraction methods to identify …
Reverse Engineering Biology: The Dawn of Microphysiological Systems Sri Harsha Paladugu Reverse engineering or backward engineering is a way to understand complex systems (such as machines, software, and protocols) and repurpose them for better applications. This process became popular during the Second World War and the Cold War, wherein each nation tried to copy the …
Reverse Engineering Biology: The Dawn of Microphysiological Systems Read More »
Microphysiological systems, which includes spheroids and microfluidic systems, enable studies to understand the underlying mechanisms of diseases and promises to accelerate the development of drugs and predict how individual patients will respond to said drugs. InSphero’s Akura™ Flow represents a plug & play concept where 3D spheroids representing various or individual organs are loaded into …
Microphysiological systems and their applications at InSphero Read More »
“Human-induced Pluripotent Cell (hiPSC) isolation and formation of organoids” Dr Mamta Mishra, M.Sc., M.Phil., Ph.D., Senior Research Scientist, Jai Research Foundation, Gujarat, India Induced pluripotent stem cells are artificial stem cells and do not exist naturally. Instead, they are generated or reprogrammed from somatic cells by ectopic expression of pluripotency factors or specific transcription factors …
Human-induced Pluripotent Cell (hiPSC) isolation and formation of organoids Read More »
Organs-on-Chips: The Future of Drug Development Sanyami Jain Those of you who love technology may be familiar with computer chips and microchips. An array of electronic circuits on a compact, flat piece of silicon is known as a chip. However, do you know that we can create human organs on a chip? This article …
Organoids in Diabetes Research Pratiksha Roham Organoids are 3D in vitro cell culture systems that are generated by differentiating embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) or adult tissue stem cells (ASCs)1. During differentiation, in addition to culture media and growth factors, stem cells require a scaffold/matrix that contains the basement membrane elements, …
