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An Original 3D Culture Model: Human Pancreatic Cancerous Organoids Generated in Liquid Pearls

An Original 3D Culture Model: Human Pancreatic Cancerous Organoids Generated in Liquid Pearls Christian D. Muller Dr. ès Sciences, Ph.D. CSO & Founder, PearlBioSystem  In recent years, interest in medicinal Cannabis sativa L. has been rising, as legislation is moving in the right direction. In our laboratory we compared different cannabinoid extraction methods to identify …

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Reverse Engineering Biology: The Dawn of Microphysiological Systems

Reverse Engineering Biology: The Dawn of Microphysiological Systems Sri Harsha Paladugu Reverse engineering or backward engineering is a way to understand complex systems (such as machines, software, and protocols) and repurpose them for better applications. This process became popular during the Second World War and the Cold War, wherein each nation tried to copy the …

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Microphysiological systems and their applications at InSphero

Microphysiological systems, which includes spheroids and microfluidic systems, enable  studies to understand the underlying mechanisms of diseases and promises to accelerate  the development of drugs and predict how individual patients will respond to said drugs. InSphero’s Akura™ Flow represents a plug & play concept where 3D spheroids representing  various or individual organs are loaded into …

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Human-induced Pluripotent Cell (hiPSC) isolation and formation of organoids

“Human-induced Pluripotent Cell (hiPSC) isolation and formation of organoids” Dr Mamta Mishra, M.Sc., M.Phil., Ph.D., Senior Research Scientist, Jai Research Foundation, Gujarat, India Induced pluripotent stem cells are artificial stem cells and do not exist naturally. Instead, they are generated or reprogrammed from somatic cells by ectopic expression of pluripotency factors or specific transcription factors …

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Organoids in Diabetes Research

Organoids in Diabetes Research Pratiksha Roham Organoids are 3D in vitro cell culture systems that are generated by differentiating embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) or adult tissue stem cells (ASCs)1. During differentiation, in addition to culture media and growth factors, stem cells require a scaffold/matrix that contains the basement membrane elements, …

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Microscopy tools for imaging microphysiological systems

Microscopy tools for imaging microphysiological systems Surat Parvatam   A key element to enable an increase in the usage of organ-on-chip (OOC) devices in biomedical research and drug discovery is the ability to monitor and measure quantitative information from these systems at cellular level. Non-invasive imaging methods also help in long-term and live imaging of …

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Identifying genetic risk for autism spectrum disorder (ASD) using organoids

Identifying genetic risk for autism spectrum disorder (ASD) using organoids The risk for autism spectrum disorder has been associated with hundreds of genes. However, the extent of changes in the human brain as a result of mutations in these genes and the contribution of specific genes remains unclear. Additionally, the manifestation of these changes varies …

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Mimicking the micro-environment in organoids

Mimicking the micro-environment in organoids   In order to better understand the pathophysiology of cancer biology, there is a growing need for experimental in vitro models that can recapitulate not only the characteristics of tumors, but also the surrounding microenvironment of the tumor. The role of the extracellular matrix (ECM) is particularly important in the …

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Promoting cross-sectoral collaboration in microphysiological systems

Microphysiological systems have been rapidly advancing in the last few years, bringing about a paradigm change in the areas of diagnostics, disease prevention and treatment. The use of these systems is also rapidly advancing in other sectors, such as cosmetics, food, medtech, etc. However, many of these industries often work in siloes, despite the fact …

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