A first-of-its-kind study shows Liver-Chip can predict drug safety better than animal models Dr. Kasturi MahadikSenior Research AssociateCentre for Predictive Human Model Systems (CPHMS), AIC-CCMB Have you wondered about the journey of a routine tablet like aspirin before it reaches your cabinet? Did you know scientists spend over a decade (if not more!) testing these …
Keep It Simple, Stupid! Written by Anushka Banerjee | Interviewed by Kadambari Patil & Anushka Banerjee We spoke to a few members of the exciting research team in the Majumder lab at IIT-Bombay. Using microphysiological systems, they study mechanobiology by combining the principles of biology, chemistry, engineering, and physics! Their mantra? Keep it simple! “In …
Tiny Magnets Find Brain Cancer Cells Be aware! A persistent head-ache today may be a serious brain tumour tomorrow Nupur Fangaria Loka Biosciences Pvt. Ltd. A 40-year-old man has been suffering from a persistent headache with a feeling of nausea for a month. He finally visits the doctor who suggests he undergo an MRI scan. …
Organoids: More than tissue culture and not less than animal models! Karthic A SIIPL, Pune Inventing or discovering a new medicinal drug takes an average of 10 years from mind to market. It is due to the extensive regulation involved in assessing the safety and efficacy of any new active pharmaceutical ingredient in its administrable …
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3D Bioprinting Sindhu M Indian Institute of Science, Bengaluru A group of 15-20 bioengineers huddled around a machine while Vikas Garg explained how it could someday be the future of food technology. The machine is a 3D printer, which can shape silicone, a notoriously difficult material. Vikas is the co-founder of Prayasta, a startup that …
Vast Potentials of Microphysiological Systems Sudeepa Nandi Tata Institute of Fundamental Research, Mumbai With a growing need in the biomedical field, it is imminent to find the best of model systems to address basic and translational questions. For decades, 2D cultures have been used immensely, for disease modelling studies to test drugs for diseases. However, …
An Original 3D Culture Model: Human Pancreatic Cancerous Organoids Generated in Liquid Pearls Christian D. Muller Dr. ès Sciences, Ph.D. CSO & Founder, PearlBioSystem In recent years, interest in medicinal Cannabis sativa L. has been rising, as legislation is moving in the right direction. In our laboratory we compared different cannabinoid extraction methods to identify …
Reverse Engineering Biology: The Dawn of Microphysiological Systems Sri Harsha Paladugu Reverse engineering or backward engineering is a way to understand complex systems (such as machines, software, and protocols) and repurpose them for better applications. This process became popular during the Second World War and the Cold War, wherein each nation tried to copy the …
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Microphysiological systems, which includes spheroids and microfluidic systems, enable studies to understand the underlying mechanisms of diseases and promises to accelerate the development of drugs and predict how individual patients will respond to said drugs. InSphero’s Akura™ Flow represents a plug & play concept where 3D spheroids representing various or individual organs are loaded into …
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“Human-induced Pluripotent Cell (hiPSC) isolation and formation of organoids” Dr Mamta Mishra, M.Sc., M.Phil., Ph.D., Senior Research Scientist, Jai Research Foundation, Gujarat, India Induced pluripotent stem cells are artificial stem cells and do not exist naturally. Instead, they are generated or reprogrammed from somatic cells by ectopic expression of pluripotency factors or specific transcription factors …
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